Australasian Menopause Society - AMS Guide to Equivalent HRT Doses

AMS Guide to Equivalent HRT Doses

This Information Sheet has been developed as a guideline only to approximately equivalent doses of the different HRT products available 1st July 2009. The intention is to help physicians change their patients to higher or lower approximate doses of HRT if needing to tailor therapy, or remain within the same approximate dose if needing to change brands of HRT.

alt AMS Guide to Equivalent HRT Doses 355.92 Kb

Products which are underlined are Australia only; products in italics are NZ only.

Products with an * meaning Private/non PBS script.

Oestrogen & progestogen combination HRT
Cyclical oestrogen & progestogen combinations use these at peri-menopause or if less than 12 months amenorrhoea
Medium dose
Product	Presentation	Composition
Trisequens*	tablet	1,2mg oestradiol/1mg norethisterone
Estalis sequi 50/140	transdermal patch	50mcg oestradiol/140mcg norethisterone acetate
Estalis sequi 50/250 (same oestrogen, more progestogen than Estalis sequi 50/140),	transdermal patch	50mcg oestradiol/250mcg norethisterone acetate
Femoston	tablet	2mg oestradiol/10mg dydrogesterone
Nuvelle	tablet	2mg oestradiol/75mcg levonorgestrel
Continuous oestrogen & progestogen combinations should be used if 12 months since LMP or after 12 months cyclical HRT
Low dose
Product	Presentation	Composition
Angeliq1/2*	tablet	1mg oestradiol/2mg drospirenone
Kliovance*	tablet	1mg oestradiol/0.5mg norethisterone
Livial* (generally suitable for older women or at least 12 months post-menopause)	tablet	2.5mg tibolone
Medium dose
Kliogest*	tablet	2mg oestradiol/1mg norethisterone
Premia 2.5 continuous*	tablet	0.625mg conjugated equine oestrogens/2.5mg medroxyprogesterone acetate
Premia 5 continuous* (same oestrogen, more progestogen than Premia2.5 continuous)	tablet	0.625mg conjugated equine oestrogens/5mg medroxyprogesterone acetate
Estalis continuous 50/140	transdermal patch	50mcg oestradiol/140mcg norethisterone acetate
Estalis continuous 50/250 (same oestrogen, more progestogen than Estalis continuous 50/140)	transdermal patch	50mcg oestradiol/250mcg norethisterone acetate

Oestrogen only therapy only use these if patient has had a hysterectomy or in combination with a progestogen or Mirena if intact uterus
Low dose
Product	Presentation	Composition
Estrofem*, Progynova	tablet	1mg oestradiol
Ovestin	tablet	2mg oestriol
Premarin*	tablet	0.3mg conjugated equine oestrogen
Sandrena	gel	1mg oestradiol
Climara25, Estraderm25, EstradermMX25, Estradot25, Femtran25	transdermal patch	25mcg/24hrs oestradiol
Estradot37.5	transdermal patch	37.5mcg/24hrs oestradiol
Medium dose
Estrofem*, Progynova, Zumenon	tablet	2mg oestradiol
Premarin*	tablet	0.625mg conjugated equine oestrogen
Climara50, EstradermMX50, Estradot50, Femtran50,	transdermal patch	50mcg/24hrs oestradiol
Higher dose
Climara75, Estradot75	transdermal patch	75mcg/24hrs oestradiol
Climara100, Estraderm100, EstradermMX100, Estradot100, Femtran100	transdermal patch	100mcg/24hrs oestradiol
Oestradiol implants - see AMS Information Sheet
Oestrogen only vaginal therapy
Ovestin	cream	1mg/g oestriol
Ovestin ovula	pessary	0.5mg oestriol
Vagifem	pessary	25mcg oestradiol
Progestogen suggested alternative doses for use with the oestrogen preparations above where fixed dose therapy is not suitable
Low dose
Product	Presentation	Composition
Duphaston (1/4 10mg tablet)	tablet	2.5mg dydrogesterone
Provera (1/2 5mg tablet)	tablet	2.5mg medroxyprogesterone acetate
Mirena*	device (5 years)	20mcg/24hrs levonorgestrel
Low dose progestogen-only contraceptive pills (Microlut* (30mcg levonorgestrel), Noriday, Micronor (both 350 mcg norethisterone)) are used by some clinicians in various doses but there are no specific data for dosages of these pills required for endometrial protection. For further information see Cochrane Review (Cochrane Database Syst Rev. 2009 Apr 15;(2):CS000402).
Medium dose
Duphaston (1/2 10mg tablet)	tablet	5mg dydrogesterone
Provera, Ralovera	tablet	5mg medroxyprogesterone acetate
Higher dose (for use in cyclical therapy or high dose continuous therapy)
Duphaston	tablet	10mg dydrogesterone
Primolut N (1/2 5mg tablet)	tablet	2.5mg norethisterone
Provera, Ralovera	tablet	10mg medroxyprogesterone acetate

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Content Updated 1 July 2010

Last Updated (Thursday, 01 July 2010 16:52)