Description

The International Breast Cancer Intervention Study II (IBIS II) is the first study to investigate whether the breast cancer treatment drug anastrozole can prevent breast cancer from occurring in postmenopausal women at higher risk of developing the disease.  There are currently 21 countries around the world participating in this study. 10,000 women are needed worldwide and accrual passed 5100 in December 2009. Women will be required to take a daily tablet for five years and visit a clinic twice in the first year and once every year following.

The study is coordinated in Australia and New Zealand by the Australian New Zealand Breast Cancer Trials Group. The ANZ BCTG is a not-for-profit organisation and is Australia's national organisation dedicated to breast cancer research

Inclusion Criteria

• Aged between 40 and 70
• Postmenopausal
• At increased risk of breast cancer due to a family history or other risk factors
• Must not have had invasive breast cancer
• Women who have had DCIS diagnosed within the last 6 months may be eligible to join a sub-study of IBIS-II, investigating treatments for DCIS.

Geographical Location of Study

The study is currently available at 28 sites in Australia and 4 sites in New Zealand.

Principal Investigator

Australia and New Zealand - Study Chairman Professor John Forbes, Study Co-Chairman Professor John Simes. Each site has its own dedicated Principal Investigator.

Contact Details

Women who are interested in participating in this study should contact the relevant freecall number and leave their details. A study coordinator from their nearest site will contact them. 

Australia – 1800 640 709
New Zealand – 0800 888 656
Visit www.anzbctg.org for further information.

Ethics Approval

 New South Wales

• Hunter Area Research Ethics Committee, Newcastle, Australia (Newcastle Mater Misericordiae Hospital) (Prevention, DCIS & Bone)
• Human Research Ethics Committee, Newcastle, Australia (The University of Newcastle) (Prevention, DCIS & Bone)
• North Coast Area Health Service Clinical Governance Unit, Human Research Ethics Committee (Coffs Harbour Health Campus) (Prevention & Bone)
• Northern Sydney Central Coast NSW Health Human Research Ethics Committee (Royal North Shore Hospital) (DCIS)
• Riverina Cancer Care Centre, Human Research Ethics Committee (Prevention & DCIS)
• St Vincent’s & Mater Health Sydney Human Research Ethics Committee (Prevention, DCIS & Bone)
• SSWAHS Human Research Ethics Committee (RPAH Zone - Prevention & Bone), (Western Zone [Liverpool & Macarthur Cancer Therapy Centres] - Prevention, DCIS & Bone)

Queensland

• Greenslopes Private Hospital Ethics Committee – Ramsay Health Care (The Breast Centre, Gateshead) (Prevention, DCIS & Bone)
• Royal Brisbane & Women’s Hospital Health Service District Human Research Ethics Committee (Royal Brisbane & Women’s Hospital - DCIS), (Nambour General Hospital - Prevention, DCIS & Bone)

South Australia

• Government of South Australia, Central Northern Adelaide Health Service, Research Ethics Committee (Royal Adelaide Hospital) (Prevention & DCIS)

Tasmania

• Tasmania Health and Medical Human Research Ethics Committee (Hobart Private Hospital, Royal Hobart Hospital) (Prevention)

Victoria

• Austin Health, Research Ethics Unit, Human Research Ethics Committee (Prevention, DCIS & Bone)
• Eastern Health Research & Ethics Committee, (Maroondah Hospital, Box Hill Hospital) (Prevention & DCIS)
• Melbourne Health Human Research Ethics Committee (Royal Melbourne Hospital) (Prevention & DCIS)
• Mercy Health & Aged Care Research Ethics Committee (Breast Unit @ Mercy Private) (Prevention & DCIS)
• Peter MacCallum Cancer Institute Ethics Committee (Prevention)
• St Vincent’s Hospital Melbourne, Research and Grants Unit, Human Research Ethics Committee-D (Prevention, DCIS & Bone)
• Southern Health, Human Research Ethics Committee-A (Monash Medical Centre) (DCIS)

Western Australia

• The Government of Western Australia Department of Health - Human Research Ethics Committee (Sir Charles Gairdner Hospital) (Prevention)

New Zealand

• Multi-Region Ethics Committee, Ministry of Health:(Breast Associates Ltd, Canterbury Breast Care, North Shore Hospital, St Anne Breast Care, Waikato Hospital, Wellington Hospital) (Prevention & Bone)
• Northern X Regional Ethics Committee, Ministry of Health (Breast Associates Ltd, North Shore Hospital-WDHB, St Anne Breast Care, Waikato Hospital) (DCIS)

Content updated 14 January 2010