Facebook Follow AMS on Linkedin Follow us on Twitter @amsCoolAgain AMS on Instagram
  • 17th World Congress on Menopause

    17th World Congress on Menopause

    Date moved: now Melbourne
    3-7 February 2021

    Read more

  • AMS eLearning

    AMS eLearning

    A benefit for AMS Members
    webinars, case studies
    with CPD points

    Read more

  • Health Information

    Health Information

    Find an AMS Doctor, news,
    self-assessment tools and videos

    Read more

  • Menopause management

    Menopause management

    AMS supporting women through
    midlife health and the menopause

    Read more

  • Health Professionals

    Health Professionals

    Menopause management resources,
    news, position statements

    Read more

  • Menopause Videos

    Menopause Videos

    Explaining issues women
    worry most about

    Read more

AMS eLearning for Members

AMS eLearning Website

AMS eLearning is a benefit for AMS members only who will be able to access webinars, case studies, quizzes and other learning that will attract CPD points.
Members register here.

Congress News 2020

17th World Congress on the Menopause

The 17th World Congress on the Menopause in Melbourne hosted by the IMS with the support of the AMS now moved 4-7 February 2021.
Go to 17th World Congress page.

What's New | Features

What's New | Features

View the latest articles available on the AMS website. See What's New here.
View articles, resources, position statement or events of particular interest. See Features here.

AMS Fact Sheets

AMS Fact Sheets

AMS has created a set of fact sheets for patients. These documents are companion sheets to the popular videos, and our other more detailed AMS Information Sheets. The first three sheets are available. 
Learn more here.

Members

hps

If your work focuses on menopause and issues related to women's midlife health, become a Member of the AMS. Access information and resources which will inspire and guide improvements for your practice.
Members only information | Log in.

Health Professionals

Health professionals

Health Professionals includes AMS Congress updates, information sheets, menopause management resources, news, position statements, a selection of studies published, NAMS videos and more...
See Health Professionals.

HRT therapy may increase risk of acute pancreatitis

Women who use postmenopausal hormone replacement therapy (HRT) may be at increased risk of acute pancreatitis, found a new study in CMAJ (Canadian Medical Association Journal).

Acute pancreatitis, a sudden inflammation of the pancreas, has symptoms that range from mild discomfort to severe, debilitating pain and may, in some cases, even lead to death.

Although several case reports have indicated that there may be an association between use of HRT and risk of acute pancreatitis, the evidence from large studies is sparse. To understand whether there is an association, the researchers looked at data on 31 494 Swedish postmenopausal women aged 48 years at the start of the 13-year study from 1997 to 2010. At the start of the study, 13 113 (42%) of the women were current users of HRT, 3660 (12%) were previous users, and the remainder had never used the therapy. Of the current users of HRT, 6795 (52%) used systemic therapy for hot flashes, 4148 (32%) used local therapy for vaginal dryness, and 2170 (16%) used both therapies.

After taking account of factors likely to influence the results, the researchers found that women who currently or previously had used HRT had an approximately 1.5 greater risk of acute pancreatitis than those who had never used the therapy. The risk seemed to be higher among women who used systemic therapy and those who had used HRT for more than 10 years.

"There are no contemporary data that might explain our finding that the risk was sustained among past users of [HRT] or that the risk seemed to increase with duration of use," writes Dr. Viktor Oskarsson, Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, with coauthors. "These findings, though speculative, may suggest that exogenous estrogen induces some persistent change in the pancreas for which the duration of exposure may be important."

The authors suggest that if additional studies confirm these findings, physicians should consider the risk of acute pancreatitis when prescribing HRT.

Reference

Oskarsson V, Orsini N, Sadr-Azodi O, Wolk A. Postmenopausal hormone replacement therapy and risk of acute pancreatitis: a prospective cohort study. CMAJ. 2014 Jan 27. [Epub ahead of print]

 

Content updated 27 January 2014 

 

Search

Facebook Follow AMS on Linkedin Follow us on Twitter @amsCoolAgainAMS on Instagram